NF-kappaB activation is required for the development of cardiac hypertrophy in vivo.

Abstract

In the present study, we examined whether NF-kappaB activation is required for cardiac hypertrophy in vivo. Cardiac hypertrophy in rats was induced by aortic banding for 1, 3, and 5 days and 1-6 wk, and age-matched sham-operated rats served as controls. In a separate group of rats, an IkappaB-alpha dominant negative mutant (IkappaB-alphaM), a superrepressor… (More)

Topics

Cite this paper

@article{Li2004NFkappaBAI, title={NF-kappaB activation is required for the development of cardiac hypertrophy in vivo.}, author={Yuehua Li and Tuanzhu Ha and Xiang Gao and Jim L. Kelley and David Leonard Williams and I. William Browder and Race L. Kao and Chuanfu Li}, journal={American journal of physiology. Heart and circulatory physiology}, year={2004}, volume={287 4}, pages={H1712-20} }