NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.

@article{Hsu1999NFkappaBAI,
  title={NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells.},
  author={M H Hsu and Meiying Wang and Darren D Browning and Naofumi Mukaida and Richard D Ye},
  journal={Blood},
  year={1999},
  volume={93 10},
  pages={3241-9}
}
C5a, a potent peptide chemoattractant, stimulates interleukin-8 (IL-8) secretion from peripheral blood mononuclear cells (PBMC). Experiments were conducted to understand the mechanisms for C5a-induced IL-8 production, which was 14-fold greater than that in unstimulated cells by 2 hours. IL-8 secretion was accompanied by accumulation of IL-8 mRNA in the cytosol and by nuclear expression of a kappaB DNA binding activity within 30 minutes. AP-1 but not NF-IL-6 DNA binding activity was also… CONTINUE READING

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