NF-kappaB activation induced by Notch ligand stimulation in acute myeloid leukemia cells.

@article{Itoh2009NFkappaBAI,
  title={NF-kappaB activation induced by Notch ligand stimulation in acute myeloid leukemia cells.},
  author={Mai Itoh and Lu Fu and Shuji Tohda},
  journal={Oncology reports},
  year={2009},
  volume={22 3},
  pages={631-4}
}
There are conflicting reports regarding the effects of Notch activation on nuclear factor-kappaB (NF-kappaB) activity. The relationships are cell type-dependent and have not been fully elucidated. We examined the effects of Notch activation induced by a recombinant Notch ligand, Delta-like1 (Dll1), on the NF-kappaB activity in two acute myeloid leukemia (AML) cell lines. We found that Delta1-induced Notch activation activated the NF-kappaB pathway in THP-1 cells. Regarding the possible… CONTINUE READING