NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.

Abstract

The interferon (IFN)-inducible double-stranded-RNA (dsRNA)-activated serine-threonine protein kinase (PKR) is a major mediator of the antiviral and antiproliferative activities of IFNs. PKR has been implicated in different stress-induced signaling pathways including dsRNA signaling to nuclear factor kappa B (NF-kappaB). The mechanism by which PKR mediates… (More)

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Cite this paper

@article{ZamanianDaryoush2000NFkappaBAB, title={NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.}, author={Maryam Zamanian-Daryoush and Trine Hyrup Mogensen and Joseph A. DiDonato and Bryan R G Williams}, journal={Molecular and cellular biology}, year={2000}, volume={20 4}, pages={1278-90} }