NF-kappaB/p50 and NF-kappaB/c-Rel differentially regulate the activity of the 3'alphaE-hsl,2 enhancer in normal murine B cells in an activation-dependent manner.


The enhancer complex located 3' to the C(H)alpha gene in the IgH locus (3alphaE) may regulate B cell function through its ability to act as a locus control region. Multiple, functionally relevant NF-kappaB binding sites are located within the 3'alphaE. NF-kappaB subunits, especially p50 and c-Rel, have also been shown to play critical and differential roles… (More)


  • Presentations referencing similar topics