NF- kappa B2/p100 induces Bcl-2 expression.

  title={NF- kappa B2/p100 induces Bcl-2 expression.},
  author={Patrick Viatour and Mohamed Bentires-Alj and Alain Chariot and Val{\'e}rie Deregowski and Laurence de Leval and M P Merville and Vincent Bours},
  volume={17 7},
The NF-kappaB2/p100 and bcl-3 genes are involved in chromosomal translocations described in chronic lymphocytic leukemias (CLL) and non-Hodgkin's lymphomas, and nuclear factor kappaB (NF-kappaB) protects cancer cells against apoptosis. Therefore, we investigated whether this transcription factor could modulate the expression of the Bcl-2 antiapoptotic protein. Bcl-2 promoter analysis showed multiple putative NF-kappaB binding sites. Transfection assays of bcl-2 promoter constructs in HCT116… CONTINUE READING
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