NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes.

  title={NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes.},
  author={S M Kang and Alexandra Tran and Mariagrazia Grilli and Michael J Lenardo},
  volume={256 5062},
Regulation of interleukin-2 (IL-2) gene expression by the p50 and p65 subunits of the DNA binding protein NF-kappa B was studied in nontransformed CD4+ T lymphocyte clones. A homodimeric complex of the NF-kappa B p50 subunit was found in resting T cells. The amount of p50-p50 complex decreased after full antigenic stimulation, whereas the amount of the NF-kappa B p50-p65 heterodimer was increased. Increased expression of the IL-2 gene and activity of the IL-2 kappa B DNA binding site correlated… CONTINUE READING

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