NF-kappa B is required for the positive selection of CD8+ thymocytes.

  title={NF-kappa B is required for the positive selection of CD8+ thymocytes.},
  author={Thore Hettmann and Jeffrey M. Leiden},
  journal={Journal of immunology},
  volume={165 9},
To examine the role of NF-kappaB in T cell development, we analyzed thymocyte ontogeny in transgenic (mutant I-kappaBalpha (mI-kappaBalpha)) mice that express a superinhibitory form of the NF-kappaB inhibitory protein, I-kappaBalpha (I-kappaBalpha(A32/36)), under the control of the T cell-specific CD2 promoter and enhancer. Thymi from mI-kappaBalpha mice contained increased numbers of double-positive (DP) and decreased numbers of both CD4(+) and CD8(+) single-positive cells, consistent with a… CONTINUE READING
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