NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis.

Abstract

NF-(kappa)B is an important component of both autoimmunity and bone destruction in RA. NF-(kappa)B-inducing kinase (NIK) is a key mediator of the alternative arm of the NF-(kappa)B pathway, which is characterized by the nuclear translocation of RelB/p52 complexes. Mice lacking functional NIK have no peripheral lymph nodes, defective B and T cells, and… (More)

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Cite this paper

@article{Aya2005NFkappaBinducingKC, title={NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis.}, author={Kunihiko Aya and Muhammad A Alhawagri and Amanda Hagen-Stapleton and Hideki Kitaura and Osami Kanagawa and Deborah V Novack}, journal={The Journal of clinical investigation}, year={2005}, volume={115 7}, pages={1848-54} }