NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells

@inproceedings{Galardi2011NFkBAC,
  title={NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells},
  author={Silvia Galardi and Neri Mercatelli and Maria Giulia Farace and Silvia Anna Ciafr{\'e}},
  booktitle={Nucleic acids research},
  year={2011}
}
MicroRNAs (miRNAs) are potent negative regulators of gene expression involved in all aspects of cell biology. They finely modulate virtually all physiological pathways in metazoans, and are deeply implicated in all main pathologies, among which cancer. Mir-221 and miR-222, two closely related miRNAs encoded in cluster from a genomic region on chromosome X, are strongly upregulated in several forms of human tumours. In this work, we report that the ectopic modulation of NF-kB modifies miR-221… CONTINUE READING

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References

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miR-221 overexpression contributes to liver tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2010

MicroRNAs in cancer: small molecules with a huge impact.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2009

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