NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor.

  title={NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor.},
  author={Ayano Murai-Takeda and Hirotaka Shibata and Isao Kurihara and Sakiko Kobayashi and Kenichi Yokota and Noriko Suda and Yuko Mitsuishi and Rie Jo and Hirochika Kitagawa and Shigeaki Kato and Takao Saruta and Hiroshi Itoh},
  journal={The Journal of biological chemistry},
  volume={285 11},
The role of aldosterone has been implicated in the metabolic syndrome and cardiovascular diseases. The biological actions of aldosterone are mediated through mineralocorticoid receptor (MR). Nuclear receptor-mediated gene expression is regulated by dynamic and coordinated recruitment of coactivators and corepressors. To identify new coregulators of the MR, full-length MR was used as bait in yeast two-hybrid screening. We isolated NF-YC, one of the subunits of heterotrimeric transcription factor… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 11 extracted citations

Interactions of the mineralocorticoid receptor – Within and without

Molecular and Cellular Endocrinology • 2012
View 4 Excerpts
Highly Influenced

GEMIN4 functions as a coregulator of the mineralocorticoid receptor.

Journal of molecular endocrinology • 2015
View 1 Excerpt

NF-Y and the transcriptional activation of CCAAT promoters.

Critical reviews in biochemistry and molecular biology • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…