NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.

@article{Zhu2003NFYCW,
  title={NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4.},
  author={J Julius Zhu and Diane M. Giannola and Yi Zhang and Adam J Rivera and Stephen G Emerson},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2420-7}
}
The transcription factor homeobox B4 (HOXB4) is preferentially expressed in immature hematopoietic cells and implicated in the transition from primitive hematopoiesis to definitive hematopoiesis as well as in immature hematopoietic cell proliferation and differentiation. We previously identified Hox response element 1 (HxRE-1) and HxRE-2/E-box as 2 critical DNA-binding sites of the HOXB4 promoter active in hematopoietic cells and demonstrated that upstream stimulating factor 1 and 2 (USF1/2… CONTINUE READING
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The stem cell pool in Hoxb4-/- and Hoxb3/Hoxb4-/- mice is reduced due to insufficient expression in the fetal liver [abstract

  • J Bjornsson, A Brun, S. Karlsson
  • Blood
  • 2002

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