NF-Y associates with H3-H4 tetramers and octamers by multiple mechanisms.

  title={NF-Y associates with H3-H4 tetramers and octamers by multiple mechanisms.},
  author={Giuseppina Caretti and Maria Carla Motta and Roberto Mantovani},
  journal={Molecular and cellular biology},
  volume={19 12},
NF-Y is a CCAAT-binding trimer with two histonic subunits, NF-YB and NF-YC, resembling H2A-H2B. We previously showed that the short conserved domains of NF-Y efficiently bind to the major histocompatibility complex class II Ea Y box in DNA nucleosomized with purified chicken histones. Using wild-type NF-Y and recombinant histones, we find that NF-Y associates with H3-H4 early during nucleosome assembly, under conditions in which binding to naked DNA is not observed. In such assays, the NF-YB-NF… CONTINUE READING

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