NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection.

@article{Barajas2011NFE2relatedF2,
  title={NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection.},
  author={Berenice Barajas and Nam Che and F. Mei Yin and Amir Rowshanrad and Luz D. Orozco and Ke Wei Gong and Xuping Wang and Lawrence W. Castellani and Karen Reue and Aldons J. Lusis and Jes{\'u}s Araujo},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 1},
  pages={58-66}
}
OBJECTIVE To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties. METHODS AND RESULTS Nrf2 is an important transcription factor that regulates the expression of phase 2 detoxifying enzymes and antioxidant genes. Its expression in vascular cells appears to be an important factor in the protection against vascular oxidative stress and inflammation. We developed Nrf2 heterozygous (HET) and… CONTINUE READING