NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.

@article{Tanaka2008NFE2relatedF2,
  title={NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.},
  author={Yuji Tanaka and Lauren M. Aleksunes and Ronnie L Yeager and Maxwell Afari Gyamfi and Noriko Esterly and Grace L. Guo and Curtis D. Klaassen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 2},
  pages={655-64}
}
NF-E2-related factor 2 (Nrf2) is a transcription factor that is activated by oxidative stress and electrophiles that regulates the expression of numerous detoxifying and antioxidant genes. Previous studies have shown that Nrf2 protects the liver from xenobiotic toxicity; however, whether Nrf2 plays a role in lipid homeostasis in liver is not known… CONTINUE READING