NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage

@article{Li2010NFE2relatedF2,
  title={NF-E2-related factor 2 activation in PC12 cells: its protective role in manganese-induced damage},
  author={Huangyuan Li and Siying Wu and Nian Shi and Wei Ju Lin and Junyi You and Wenhua Zhou},
  journal={Archives of Toxicology},
  year={2010},
  volume={85},
  pages={901-910}
}
Manganese neurotoxicity presents with Parkinson-like symptoms that are associated with the generation of reactive oxygen species. Thus, its occurrence and severity can be reduced by cellular antioxidants. The components of the transcription factor NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway are the central regulators of cellular antioxidant responses. In this study, we investigated the role of activation of Nrf2 in response to oxidative damage induced by manganese… CONTINUE READING

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