NF-B-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3 , the protein involved in limb-girdle muscular dystrophy type 2 A

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a recessive genetic disorder caused by mutations in the cysteine protease calpain 3 (CAPN3) that leads to selective muscle wasting. We previously showed that CAPN3 deficiency is associated with a profound perturbation of the NFB/I B survival pathway. In this study, the consequences of altered NFB/I B… (More)