NF-AT5 is a critical regulator of inflammatory arthritis.

  title={NF-AT5 is a critical regulator of inflammatory arthritis.},
  author={Hyung-Ju Yoon and Sungyong You and Seung-ah Yoo and Nam-Hoon Kim and Hyug Moo Kwon and C Yoon and C Cho and Daehee Hwang and W. Kim},
  journal={Arthritis and rheumatism},
  volume={63 7},
OBJECTIVE To investigate the role of NF-AT5, an osmoprotective transcription factor, in synovial hyperplasia and angiogenesis in patients with rheumatoid arthritis (RA). METHODS The expression of NF-AT5 in synovial tissue and synoviocytes from RA patients was examined by immunohistochemistry and Western blot analysis, respectively. Messenger RNA (mRNA) in RA synoviocytes and human umbilical vein endothelial cells (HUVECs) transfected with dummy small interfering RNA (siRNA) or NF-AT5 siRNA… CONTINUE READING
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