NF-AT components define a family of transcription factors targeted in T-cell activation

@article{Northrop1994NFATCD,
  title={NF-AT components define a family of transcription factors targeted in T-cell activation},
  author={Jeffrey P. Northrop and Steffan N. Ho and Lei Chen and Daryl J. Thomas and Luika A. Timmerman and Garry P. Nolan and Arie Admon and Gerald R Crabtree},
  journal={Nature},
  year={1994},
  volume={369},
  pages={497-502}
}
THE NF-AT transcription complex1 is required for the expression of a group of proteins that collectively coordinate the immune response2–4 . Here we purify two proteins encoded by separate genes that represent the pre-existing (p) and cytosolic (c) components of NF-AT. Expression of the full-length complementary DNA enco-ding NF-ATc activates the interleukin (IL-2) promoter in non-T lymphocytes, whereas a dominant negative of NF-ATc specifically blocks activation of the IL-2 promoter in T… CONTINUE READING
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