NF-κB-mediated induction of autophagy in cardiac ischemia/reperfusion injury.

  title={NF-κB-mediated induction of autophagy in cardiac ischemia/reperfusion injury.},
  author={Min Zeng and Xin Yu Wei and Zhiyong Wu and Wei Li and Bing Li and Ying Zhen and Jixiong Chen and Ping Wang and Yi Fei},
  journal={Biochemical and biophysical research communications},
  volume={436 2},
Ischemia/reperfusion (I/R) injury severely attenuates the benefit of revascularization after acute myocardial infarction, in which transcription factor NF-κB plays an important role. Recently, there is increasing evidence to suggest that autophagy is involved in this process. We sought to define the role of NF-κB in the induction of autophagy during cardiac I/R injury. The left circumflex coronary arteries of New Zealand white rabbits were ligated for 1.5h, followed by reperfusion for 1h to… CONTINUE READING
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