NF-κB is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea.

@article{Lee2012NFBIT,
  title={NF-κB is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea.},
  author={Jeong Goo Lee and Eunduck P Kay},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 3},
  pages={1530-8}
}
PURPOSE To determine the role of nuclear factor-κB (NF-κB) during FGF-2-mediated endothelial mesenchymal transformation (EMT) in response to interleukin (IL)-1β stimulation in corneal endothelial cells (CECs). METHODS Expression and/or activation of IL-1 receptor-associated protein kinase (IRAK), TNF receptor-associated factor 6 (TRAF6), phosphatidylinositol 3-kinase (PI 3-kinase), IκB kinase (IKK), IκB, NF-κB, and FGF-2 were analyzed by immunoblot analysis. Cell proliferation was measured by… CONTINUE READING

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