NF-κB is a target of AKT in anti-apoptotic PDGF signalling

@article{Romashkova1999NFBIA,
  title={NF-$\kappa$B is a target of AKT in anti-apoptotic PDGF signalling},
  author={J Romashkova and Sergei S. Makarov},
  journal={Nature},
  year={1999},
  volume={401},
  pages={86-90}
}
The mechanisms of cell proliferation and transformation are intrinsically linked to the process of apoptosis: the default of proliferating cells is to die unless specific survival signals are provided. Platelet-derived growth factor (PDGF) is a principal survival factor that inhibits apoptosis and promotes proliferation, but the mechanisms mediating its anti-apoptotic properties are not completely understood. Here we show that the transcription factor NF-κB is important in PDGF signalling. NF… 

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