NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Abstract

The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cellular damage and stress, has increased activity with aging and aging-related chronic diseases. To determine whether NF-κB drives aging in response to the accumulation of spontaneous, endogenous DNA damage, we measured the activation of NF-κB in WT and progeroid model mice. As both WT and progeroid mice aged, NF-κB was activated stochastically in a variety of cell types. Genetic depletion of one allele of the p65 subunit of NF-κB or treatment with a pharmacological inhibitor of the NF-κB-activating kinase, IKK, delayed the age-related symptoms and pathologies of progeroid mice. Additionally, inhibition of NF-κB reduced oxidative DNA damage and stress and delayed cellular senescence. These results indicate that the mechanism by which DNA damage drives aging is due in part to NF-κB activation. IKK/NF-κB inhibitors are sufficient to attenuate this damage and could provide clinical benefit for degenerative changes associated with accelerated aging disorders and normal aging.

DOI: 10.1172/JCI45785

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@article{Tilstra2012NFBID, title={NF-κB inhibition delays DNA damage-induced senescence and aging in mice.}, author={Jeremy S. Tilstra and Andria Rasile Robinson and Jin Wang and Siobh{\'a}n Q Gregg and Cheryl L. Clauson and Daniel P Reay and Luigi Aurelio Nasto and Claudette M. St Croix and Arvydas Ūsas and Nam Viet Vo and Johnny Huard and Paula R. Clemens and Donna B Stolz and Denis C . Guttridge and Simon C Watkins and George A Garinis and Yinsheng Wang and Laura J. Niedernhofer and Paul D . Robbins}, journal={The Journal of clinical investigation}, year={2012}, volume={122 7}, pages={2601-12} }