NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

  title={NF-κB inhibition delays DNA damage-induced senescence and aging in mice.},
  author={Jeremy S. Tilstra and Andria Rasile Robinson and Jin Wang and Siobh{\'a}n Q. Gregg and Cheryl L. Clauson and Daniel P Reay and Luigi Aurelio Nasto and Claudette M St Croix and Arvydas Ūsas and Nam Vo and Johnny Huard and Paula R. Clemens and Donna B Stolz and Denis C. Guttridge and Simon C. Watkins and George A Garinis and Yinsheng Wang and Laura J. Niedernhofer and Paul D. Robbins},
  journal={The Journal of clinical investigation},
  volume={122 7},
The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cellular damage and stress, has increased activity with aging and aging-related chronic diseases. To determine whether NF-κB drives aging in response to the accumulation of spontaneous, endogenous DNA… CONTINUE READING
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