NF-κB in cancer: a matter of life and death.

  title={NF-κB in cancer: a matter of life and death.},
  author={Bharat Bhushan Aggarwal and Bokyung Sung},
  journal={Cancer discovery},
  volume={1 6},
Activation of NF-κB has been linked to various cellular processes in cancer, including inflammation, transformation, proliferation, angiogenesis, invasion, metastasis, chemoresistance, and radioresistance. Although acute inflammation mediates innate and humoral immunity, chronic inflammation has been linked to tumorigenesis. Thus, inhibition of NF-κB has therapeutic potential in sensitization of tumors to chemotherapeutic agents; however, generalized suppression of NF-κB can result in serious… CONTINUE READING
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and its role in cancer : ‘ one size does not fit all

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