NF-κB in Cellular Senescence and Cancer Treatment

  title={NF-$\kappa$B in Cellular Senescence and Cancer Treatment},
  author={Hua Jing and Soyoung Lee},
  journal={Molecules and Cells},
  pages={189 - 195}
The NF-κB pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-κB in cancer cells, recent findings postulate that NF-κB participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-κB. In this review, we discuss implications of the NF-κB signaling pathway in cancer. Particularly, we… 

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