NF-κB functions in synaptic signaling and behavior

  title={NF-$\kappa$B functions in synaptic signaling and behavior},
  author={Mollie K. Meffert and Jolene M Chang and Brian J. Wiltgen and Michael S. Fanselow and David Baltimore},
  journal={Nature Neuroscience},
Ca2+-regulated gene transcription is essential to diverse physiological processes, including the adaptive plasticity associated with learning. We found that basal synaptic input activates the NF-κB transcription factor by a pathway requiring the Ca2+/calmodulin-dependent kinase CaMKII and local submembranous Ca2+ elevation. The p65:p50 NF-κB form is selectively localized at synapses; p65-deficient mice have no detectable synaptic NF-κB. Activated NF-κB moves to the nucleus and could directly… 
Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at
NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling
A novel hierarchical transcriptional network involving NF-κB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-β in learning and memory is disclosed.
NF-κB in Neurons
All of the evidence collected thus far indicates that NF-κB may represent a vital part of the molecular machinery involved in mammalian cognition, and is engaged in and are necessary for formation of synaptic plasticity and long-term memory.
Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development
It is revealed that NF-κB enriched in dendritic spines (the postsynaptic sites of excitatory contacts) is selectively required for NF-kkB activation by synaptic stimulation and normal dendrite spine development, which supports spatial localization at synapses as a key variable mediating selective stimulus–response coupling.
Physiological functions for brain NF-κB
NF-κB in Brain Diseases
In this chapter, the general structure, major functions, and the regulation of NF-κB signaling are first described concisely and advances made in understanding of the roles in the central nervous system and in brain diseases are reviewed in more detail.
Roles for NF-κB in Regulating Gene Expression in Synaptic Plasticity and Memory
Previous studies have shown roles for some of these proteins in CNS disorders, where a rapidly growing literature supports the involvement of NF-κB, not only in neurodegenerative conditions, but also in synaptic plasticity and memory.
A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis
A distinct role for NF-κB is defined in imparting transcriptional regulation required for the induction of changes to, but not maintenance of, excitatory synapse and spine density.
NF-kappaB in the nervous system.
Inhibition of NF-kappaB in glia might ameliorate disease, whereas activation in neurons might enhance memory, and this review focuses on results produced by the analysis of genetic models.


Retrograde Transport of Transcription Factor NF-κB in Living Neurons*
In addition to its role as a transcription factor, NF-κB may be a signal transducer, transmitting transient glutamatergic signals from distant sites to the nucleus.
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
It is shown that NF-ATc4/NF-AT3 in hippocampal neurons can rapidly translocate from cytoplasm to nucleus and activate NF-at-dependent transcription in response to electrical activity or potassium depolarization, and that induction of the inositol 1,4,5-trisphosphate receptor type 1 is controlled by the calcium/calcineurin/ NF- ATc pathway.
NF-kappa B: a crucial transcription factor for glial and neuronal cell function.
NF-kappa B can be considered as one of the most important transcription factors characterized in brain to date and it might be as crucial for neuronal and glial cell function as it is for immune cells.
NF-kB: a crucial transcription factor for glial and neuronal cell function
Brain synapses contain inducible forms of the transcription factor NF-κB
Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
A physiological role for NF-κB in maintaining survival of central neurons is demonstrated and induction of NF-σB activity increased levels of anti-apoptotic proteins and was strongly neuroprotective.
Evidence for the involvement of TNF and NF‐κB in hippocampal synaptic plasticity
Experiments in the hippocampal slice preparation suggest important roles for TNF and signaling pathways that modulate NF‐κB activity in regulation of hippocampal synaptic plasticity.
Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway
A functional knock-in technique to investigate the features of LTCs that specifically couple them to the signaling pathways that regulate gene expression found that an isoleucine-glutamine motif in the carboxyl terminus of the LTC that binds Ca2-calmodulin (CaM) is critical for conveying the Ca2+ signal to the nucleus.
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
In hippocampal neurons, signaling to CREB can be activated by nuclear calcium alone and does not require import of cytoplasmic proteins into the nucleus, which is critical for CREB-mediated transcription by synaptic NMDA receptors.