NF-κB functions in synaptic signaling and behavior

@article{Meffert2003NFBFI,
  title={NF-$\kappa$B functions in synaptic signaling and behavior},
  author={Mollie K. Meffert and Jolene M Chang and Brian J. Wiltgen and Michael S. Fanselow and David Baltimore},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={1072-1078}
}
Ca2+-regulated gene transcription is essential to diverse physiological processes, including the adaptive plasticity associated with learning. We found that basal synaptic input activates the NF-κB transcription factor by a pathway requiring the Ca2+/calmodulin-dependent kinase CaMKII and local submembranous Ca2+ elevation. The p65:p50 NF-κB form is selectively localized at synapses; p65-deficient mice have no detectable synaptic NF-κB. Activated NF-κB moves to the nucleus and could directly… 
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