NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.

  title={NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.},
  author={J. Brown and C. Lin and Q. Duan and Gabriel K. Griffin and Alexander Federation and Ronald M. Paranal and Steven M. Bair and G. Newton and A. Lichtman and A. Kung and T. Yang and H. Wang and F. Luscinskas and K. Croce and J. Bradner and J. Plutzky},
  journal={Molecular cell},
  volume={56 2},
  • J. Brown, C. Lin, +13 authors J. Plutzky
  • Published 2014
  • Medicine, Biology
  • Molecular cell
  • Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to master regulatory transcription factors. To explore the role of chromatin-dependent signal transduction in the atherogenic inflammatory response, we characterized the dynamics, structure, and function of regulatory elements in the activated endothelial cell epigenome. Stimulation with tumor necrosis factor alpha prompted a dramatic and rapid global redistribution of chromatin activators to massive de novo… CONTINUE READING

    Figures and Topics from this paper.

    Paper Mentions

    The main OBJECTIVE of this proposal is to extend the investigator's preclinical findings on the role of epigenetics and DNA damage and Bromodomain-Containing Protein 4 (BRD4) inhibition… Expand
    ConditionsPulmonary Arterial Hypertension
    Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs
    • 99
    • Highly Influenced
    • PDF
    BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.
    • 114
    • Highly Influenced
    • PDF


    Publications referenced by this paper.
    Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.
    • 437
    Suppression of inflammation by a synthetic histone mimic
    • 1,052
    • Highly Influential
    Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation
    • 1,043
    • PDF
    BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
    • 244
    Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
    • 1,976
    Latent Enhancers Activated by Stimulation in Differentiated Cells
    • 521
    Duration of nuclear NF-kappaB action regulated by reversible acetylation.
    • 459
    BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
    • 1,922
    Control of NF-kappaB-dependent transcriptional responses by chromatin organization.
    • 82
    • Highly Influential
    • PDF