NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.

@article{Brown2014NFBDD,
  title={NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.},
  author={J. Brown and C. Lin and Q. Duan and Gabriel K. Griffin and Alexander Federation and Ronald M. Paranal and Steven M. Bair and G. Newton and A. Lichtman and A. Kung and T. Yang and H. Wang and F. Luscinskas and K. Croce and J. Bradner and J. Plutzky},
  journal={Molecular cell},
  year={2014},
  volume={56 2},
  pages={
          219-231
        }
}
  • J. Brown, C. Lin, +13 authors J. Plutzky
  • Published 2014
  • Medicine, Biology
  • Molecular cell
  • Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to master regulatory transcription factors. To explore the role of chromatin-dependent signal transduction in the atherogenic inflammatory response, we characterized the dynamics, structure, and function of regulatory elements in the activated endothelial cell epigenome. Stimulation with tumor necrosis factor alpha prompted a dramatic and rapid global redistribution of chromatin activators to massive de novo… CONTINUE READING

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