NF-κB as a target for oncogenic viruses.

  title={NF-κB as a target for oncogenic viruses.},
  author={Shao-Cong Sun and Ethel Cesarman},
  journal={Current topics in microbiology and immunology},
NF-κB is a pivotal transcription factor that controls cell survival and proliferation in diverse physiological processes. The activity of NF-κB is tightly controlled through its cytoplasmic sequestration by specific inhibitors, IκBs. Various cellular stimuli induce the activation of an IκB kinase, which phosphorylates IκBs and triggers their proteasomal degradation, causing nuclear translocation of activated NF-κB. Under normal conditions, the activation of NF-κB occurs transiently, thus… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-10 of 277 references

Deregulation of NF-kappaB and its upstream kinases in cancer.

Cancer metastasis reviews • 2003
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…