NF-κB and chromatin: ten years on the path from basic mechanisms to candidate drugs.

Abstract

Release of nuclear factor κΒ (NF-κB) dimers from the inhibitors of NF-κΒ (IκBs) and their subsequent nuclear translocation are only the initial events leading to the induction of NF-κB-regulated genes. Once in the nucleus, NF-κB dimers must gain access to their cognate sites in target genes. While some sites are found in a constitutively accessible state… (More)
DOI: 10.1111/j.1600-065X.2012.01103.x

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Cite this paper

@article{Natoli2012NFBAC, title={NF-κB and chromatin: ten years on the path from basic mechanisms to candidate drugs.}, author={Gioacchino Natoli}, journal={Immunological reviews}, year={2012}, volume={246 1}, pages={183-92} }