NF-κB and STAT3 – key players in liver inflammation and cancer

  title={NF-κB and STAT3 – key players in liver inflammation and cancer},
  author={Guobin He and Michael Karin},
  journal={Cell Research},
Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is one of the most deadly human cancers. The pathogenesis of HCC is frequently linked with continuous hepatocyte death, inflammatory cell infiltration and compensatory liver regeneration. Understanding the molecular signaling pathways driving or mediating these processes during liver tumorigenesis is important for the identification of novel therapeutic targets for this dreadful disease. The classical IKKβ-dependent NF-κB… CONTINUE READING
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