NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis

@inproceedings{Biswas2004NFBAI,
  title={NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis},
  author={Debajit K. Biswas and Qian Hua Shi and Shanon Baily and Ian G. Strickland and Sankar Ghosh and Arthur Beck Pardee and James Dirk Iglehart},
  year={2004}
}
Lack of molecular targets in estrogen receptor-negative (ER-negative) breast cancer is a major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in carcinoma cell lines. Activated NF-κB was detected predominantly in ER-negative vs. ER-positive breast tumors and mostly in ER-negative and ErbB2-positive tumors (86%). These in vivo results demonstrate association of activated NF-κB with a subgroup of human breast tumors and are consistent with previously reported in vitro… CONTINUE READING

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