NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

  title={NF-$\kappa$B activation by tumour necrosis factor requires the Akt serine–threonine kinase},
  author={Osman Nidai Ozes and Lindsey D. Mayo and Jason A. Gustin and Suzanne R. Pfeffer and Lawrence M. Pfeffer and David B Donner},
Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the successive action of NF-κB-inducing kinase (NIK) and an IκB-kinase (IKK) complex composed of IKKα and IKKβ. Here we show that the Akt serine–threonine kinase is involved in the activation of NF-κB by tumour necrosis factor (TNF). TNF activates phosphatidylinositol-3-OH kinase (PI(3)K) and its downstream target Akt (protein kinase B). Wortmannin (a PI(3)K inhibitor), dominant-negative PI(3)K or kinase… 
Akt Is a Downstream Target of NF-κB*
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Phosphatidylinositol 3-Kinase as a Mediator of TNF-Induced NF-κB Activation1
The results indicate that a PI 3-kinase-regulated step in TNF-signaling is critical for the expression of NF-κB-dependent genes.
The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity*
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Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation
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Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I
It is demonstrated that both NIK and IKKα are essential for the induction of NF-κB through LTβR, whereas the NIK–IKKα pathway is dispensable in TNFR-I signaling.


NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
Activation of the transcription factor NF-κB by inflammatory cytokines involves the successive action of NF-κB-inducing kinase (NIK) and two IκB kinases, IKK-α and IKK-β. Here we show that NIK
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Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A large multiprotein
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MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
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