NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

@article{Sudhakar2009NFBMT,
  title={NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB},
  author={Cherukuri Sudhakar and Ananthamurthy Nagabhushana and Nishant Sudhir Jain and Ghanshyam Swarup},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1601 - 1610}
}
Optineurin is a ubiquitously expressed multifunctional cytoplasmic protein encoded by OPTN gene. The expression of optineurin is induced by various cytokines. Here we have investigated the molecular mechanisms which regulate optineurin gene expression and the relationship between optineurin and nuclear factor kappaB (NF-kappaB). We cloned and characterized human optineurin promoter. Optineurin promoter was activated upon treatment of HeLa and A549 cells with tumor necrosis factor alpha… CONTINUE READING
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