NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB

@article{Jono2004NFBIE,
  title={NF-$\kappa$B Is Essential for Induction of CYLD, the Negative Regulator of NF-$\kappa$B},
  author={Hirofumi Jono and Jae Hyang Lim and Lin-Feng Chen and Haidong Xu and Eirini Trompouki and Zhixing K. Pan and George Mosialos and Jian-Dong Li},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={36171 - 36174}
}
The transcription factor NF-κB regulates genes involved in inflammatory and immune responses, tumorigenesis, and apoptosis. In contrast to the pleiotropic stimuli that lead to its positive regulation, the known signaling mechanisms that underlie the negative regulation of NF-κB are very few. Recent studies have identified the tumor suppressor CYLD, loss of which causes a benign human syndrome called cylindromatosis, as a key negative regulator for NF-κB signaling by deubiquitinating tumor… 

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