NF-κB Activity Is Required for the Deregulation of c-myc Expression by the Immunoglobulin Heavy Chain Enhancer*

@article{Kanda2000NFBAI,
  title={NF-$\kappa$B Activity Is Required for the Deregulation of c-myc Expression by the Immunoglobulin Heavy Chain Enhancer*},
  author={Kayoko Kanda and H. M. Hu and L Zhang and J Grandchamps and Linda M. Boxer},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={32338 - 32346}
}
The c-myc gene is translocated to one of the immunoglobulin genes in Burkitt's lymphoma resulting in deregulated expression of c-myc. Several enhancers have been shown to be important for expression of the immunoglobulin heavy chain gene. Four enhancer regions (murine-hypersensitive sites (MHS) 1, 2, 3, and 4) located 3′ of the murine immunoglobulin heavy chain gene play a role in activating expression of the translocated c-myc gene. The enhancer regions also result in a shift in… 

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