NF-κB, inflammation, immunity and cancer: coming of age

@article{Taniguchi2018NFBII,
  title={NF-$\kappa$B, inflammation, immunity and cancer: coming of age},
  author={Koji Taniguchi and Michael Karin},
  journal={Nature Reviews Immunology},
  year={2018},
  volume={18},
  pages={309-324}
}
Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding… 
View on Nature
ncbi.nlm.nih.gov
1,049 Citations
Highly Influential Citations
27
Background Citations
276
Methods Citations
2
Results Citations
3

1,049 Citations

NF-κB and Its Role in Checkpoint Control
TLDR
This review discusses recent evidence for an association of NF-κB and immune checkpoint expression and examines the therapeutic potential of inhibitors targeting either NF-σB directly or molecules involved in NF-β regulation in combination with immune checkpoint blockade.
NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
TLDR
This review covers general themes that have emerged regarding the biological roles and mechanisms by which NF-κB contributes to human cancers and new thoughts on how NF-σB may be targeted for cancer prognosis or therapy.
NF-κB in Gastric Cancer Development and Therapy
TLDR
This review addresses recent knowledge about the mechanisms and consequences of NF-κB dysregulation in gastric cancer development and therapy.
NF-κB Signaling and Inflammation – Drug Repurposing to Treat Inflammatory Disorders?
TLDR
Drug repurposing strategies are a promising alternative to de-novo drug development, as they minimize drug development timelines and reduce the risk of failure due to unexpected side effects.
NF-κB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders?
TLDR
This paper critically review NF-κB as a potential target for the development of anti-inflammatory drugs with an emphasis on drug repurposing as a strategy to identify new approaches to treat inflammatory diseases.
Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation
Helminth‐derived molecules inhibit colitis‐associated colon cancer development through NF‐κB and STAT3 regulation
TLDR
This study demonstrates a remarkable effect of helminth‐derived molecules on suppressing ongoing colorectal cancer by downregulating proinflammatory and protumorigenic signaling pathways.
NF‐κB signaling in inflammation and cancer
TLDR
This review aims to summarize the knowledge of the family members of NF‐κB, as well as the basic mechanisms of NF-κB signaling pathway activation, and the effects of dysregulated NF‐σB on inflammation, tumorigenesis, and tumor microenvironment.
Advancement of NF-κB Signaling Pathway: A Novel Target in Pancreatic Cancer
TLDR
This review focused on emphasizing the recent advancements in the involvement of NF-κB in PADC’s progression and resistance, and highlighted the interaction of NF -κB with other signaling pathways.
Subunit-Specific Role of NF-κB in Cancer
TLDR
Overexpression data of the NF-κB subunits RELA, RELB, and c-REL as well as of their upstream kinase inhibitor, namely inhibitor of κB kinases (IKK), in different human cancers, assessed by database mining are argued against a universal mechanism of cancer-mediated activation and suggest a much more elaborated mode of NF-kkB regulation.
...
...

References

SHOWING 1-10 OF 315 REFERENCES
NF-κB: linking inflammation and immunity to cancer development and progression
TLDR
The hypothesis is put forward that activation of nuclear factor-κB by the classical, IKK-β (inhibitor-of-NF-β kinase-β)-dependent pathway is a crucial mediator of inflammation-induced tumour growth and progression, as well as an important modulator of tumour surveillance and rejection.
Inflammation meets cancer, with NF-κB as the matchmaker
TLDR
Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors.
Nuclear factor-κB in cancer development and progression
TLDR
NF-κB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.
NF-κB functions as a tumour promoter in inflammation-associated cancer
TLDR
It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
The diverse and complex roles of NF-κB subunits in cancer
TLDR
If the NF-κB pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-σκB subunits.
Cancer secretome and inflammation: The bright and the dark sides of NF-κB.
NF-κB in Cellular Senescence and Cancer Treatment
TLDR
This review discusses implications of the NF-κB signaling pathway in cancer, and emphasizes the connection of NF-σB with cellular senescence as a response to chemotherapy, and presents examples how distinct oncogenic network contexts surrounding NF-KKB produce fundamentally different treatment outcomes in aggressive B-cell lymphomas.
p53 and the Carcinogenicity of Chronic Inflammation.
TLDR
The antagonistic relationship between p53 and NF-κB is controlled by multiple mechanisms and reflects cardinal differences in organismal responses to intrinsic and extrinsic cell stresses driven by these two transcription factors, respectively.
The NF-κB Pathway and Cancer Stem Cells
TLDR
The evidence for a role for NF-κB signaling in cancer stem cell biology is examined and it is found that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis.
Microbiome, Inflammation, and Cancer
TLDR
This review will provide a general overview of commensal microbiota, inflammation, and cancer, as well as how microbes fit into this emerging field.
...
...