NF-κ B p 100 limits TNF-induced bone resorption in mice by a TRAF 3-dependent mechanism

@inproceedings{Yao2009NFBP,
  title={NF-κ B p 100 limits TNF-induced bone resorption in mice by a TRAF 3-dependent mechanism},
  author={Zhenqiang Yao and Lianping Xing and Brendan F. Boyce},
  year={2009}
}
TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-κB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast formation in vitro. However, unlike RANKL, TNF does not activate the alternative NF-κB pathway efficiently to process the IκB protein NF-κB p100 to NF-κB p52, nor does it appear to induce osteoclast formation in vivo in the absence of RANKL. Here, we show that TNF limits RANKLand TNF-induced… CONTINUE READING

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