NF-κ B : a key role in inflammatory diseases

  title={NF-κ B : a key role in inflammatory diseases},
  author={Paul Peter Tak and Gary S. Firestein},
Activation of the NF-κB/Rel transcription family, by nuclear translocation of cytoplasmic complexes, plays a central role in inflammation through its ability to induce transcription of proinflammatory genes (1). This pathway is activated upon appropriate cellular stimulation, most often by signals related to pathogens or stress. Here we will discuss the specificity of various NF-κB proteins, their role in inflammatory disease, the regulation of NF-κB activity by IκB proteins and IκB kinase (IKK… CONTINUE READING
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Effect of a T cell specific NF-kB inhibitor on in vitro cytokine production and collagen-induced arthritis

  • Gerlag, D.M
  • J. Immunol
  • 2000

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