NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation

@inproceedings{Nivon2016NFBIA,
  title={NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation},
  author={Mathieu Nivon and Lo{\"i}c Fort and Pascale Muller and Emma Richet and St{\'e}phanie Simon and Baptiste Guey and Ma{\"e}lenn Fournier and Andr{\'e}-Patrick Arrigo and Claudio Hetz and Julie D. Atkin and Carole Kretz-remy},
  booktitle={Molecular biology of the cell},
  year={2016}
}
During cell life, proteins often misfold, depending on particular mutations or environmental changes, which may lead to protein aggregates that are toxic for the cell. Such protein aggregates are the root cause of numerous diseases called "protein conformational diseases," such as myofibrillar myopathy and familial amyotrophic lateral sclerosis. To fight against aggregates, cells are equipped with protein quality control mechanisms. Here we report that NFκB transcription factor is activated by… CONTINUE READING