NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

@article{Lian2015NFBActivatedAR,
  title={NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease},
  author={Hong Lian and Li Yang and Allysa L Cole and Lu Sun and Angie Chiang and Stephanie W. Fowler and David J Shim and Jennifer Rodriguez-Rivera and Giulio Taglialatela and Joanna L. Jankowsky and Hui-Chen Lu and Hui Zheng},
  journal={Neuron},
  year={2015},
  volume={85},
  pages={101-115}
}
  • Hong Lian, Li Yang, +9 authors Hui Zheng
  • Published in Neuron 2015
  • Medicine, Biology
  • Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the signaling pathways governing NFκB regulation and function in the brain are poorly understood. We identify complement protein C3 as an astroglial target of NFκB and show that C3 release acts through neuronal C3aR to disrupt dendritic morphology and network function. Exposure to Aβ activates astroglial NFκB and C3 release, consistent with the high levels of C3 expression in brain tissue from AD patients and APP… CONTINUE READING

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