NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis.

@article{Poeppelmann2005NFkappaBdependentDO,
  title={NF\{kappa\}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis.},
  author={Birgit Poeppelmann and Kerstin Klimmek and Elwira A Strozyk and Reinhard K Voss and Thomas Schwarz and Dagmar Kulms},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 16},
  pages={15635-43}
}
Activation of the transcription factor nuclear factor-kappaB (NFkappaB) by inflammatory cytokines like tumor necrosis (TNF) factor and interleukin-1 (IL-1) is generally associated with the induction of antiapoptotic pathways. Therefore, NFkappaB inhibits both intrinsically and extrinsically induced apoptosis and thus is regarded to act universally in an antiapoptotic fashion. Accordingly, activation of NFkappaB by IL-1 was shown to result in reduction of death ligand-induced apoptosis via up… CONTINUE READING

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