NEURONAL NETWORK OF PANIC DISORDER: THE ROLE OF THE NEUROPEPTIDE CHOLECYSTOKININ

@article{Zwanzger2012NEURONALNO,
  title={NEURONAL NETWORK OF PANIC DISORDER: THE ROLE OF THE NEUROPEPTIDE CHOLECYSTOKININ},
  author={Peter Zwanzger and Katharina Domschke and Jacques Bradwejn},
  journal={Depression and Anxiety},
  year={2012},
  volume={29}
}
Panic disorder (PD) is characterized by panic attacks, anticipatory anxiety and avoidance behavior. Its pathogenesis is complex and includes both neurobiological and psychological factors. With regard to neurobiological underpinnings, anxiety in humans seems to be mediated through a neuronal network, which involves several distinct brain regions, neuronal circuits and projections as well as neurotransmitters. 

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References

SHOWING 1-10 OF 193 REFERENCES

Toward an integrated neurobiology of panic disorder.

An integrated neurobiology of panic disorder will provide a broader conceptual framework with which to tackle the complex questions about the pathophysiology and treatment of this condition.

Elevated plasma levels of neuropeptide Y in patients with panic disorder.

Higher plasma neuropeptide Y-like immunoreactivity suggests that this peptide may be implicated in the etiology or expression of symptoms of panic disorder.

Cholecystokinin-Tetrapeptide Induces Panic Attacks in Patients with Panic Disorder *

Cholecystokinin-tetrapeptide (CCK-4) and placebo were injected to 11 panic disorder patients. CCK-4 induced a panic attack identical to spontaneous panic attacks in all patients; placebo did not

Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings.

The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection, which opens the doors for studies of the effects of drug treatment on CCk-4-induced panic.

Neuroanatomical circuits modulating fear and anxiety behaviors

  • D. Charney
  • Psychology, Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 2003
Objective:  Our understanding of the neurobiology of anxiety disorders, although not complete, has advanced significantly with the development and application of genetic, neuroimaging and

Imipramine antagonism of the panicogenic effects of cholecystokinin tetrapeptide in panic disorder patients.

It is demonstrated that imipramine can antagonize the panicogenic effects of CCK-4, and a marked reduction in the number and intensity of panic symptoms, duration of symptoms, frequency of panic attacks, and cardiovascular responsiveness.

Neuroanatomical hypothesis of panic disorder, revised.

Medications, particularly those that influence the serotonin system, are hypothesized to desensitize the fear network from the level of the amygdala through its projects to the hypothalamus and the brainstem, and effective psychosocial treatments may also reduce contextual fear and cognitive misattributions.

Neuropeptide S receptor gene — converging evidence for a role in panic disorder

Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further
...