author={D. Wathes and B. Pickering and R. W. Swann and D. G. Porter and M. Hull and J. Drife},
  journal={The Lancet},
Abstract Oxytocin-like activity and vasopressin-like activity have been identified and measured by radioimmunoassay in extracts from human ovaries. The authenticity of the oxytocin was confirmed by its behaviour on high-performance liquid chromatography. The yields of both hormones were too great to be explained by known circulating levels in non-pregnant women. This suggests that these hormones are either taken up by the ovary from a neurohypophysial source or else manufactured locally, and… Expand

Topics from this paper

Identification of oxytocin and vasopressin in the testis and in adrenal tissue
The concentrations of the hormone were too great to be explained by known circulating levels of the polypeptides, and their presence in steroid secreting organs suggests a possible role for them in steroidogenesis. Expand
Identification of neurohypophysial peptides in the ovaries of several mammalian and nonmammalian species
Ovarian tissue from a variety of mammalian and nonmammalian species were extracted in acid and analysis by high performance liquid chromatography revealed the presence of oxytocin in all ovarian extracts examined. Expand
Neurohypophysial Peptides in the Gonads
The recent discovery by Wathes and Swann that ovine corpus luteum contains significant amounts of a substance with the biological, immunoreactive and Chromatographie properties of oxytocin has focussed attention on the presence of ‘neurohypophysial’ peptides in the gonads and their possible roles in reproduction. Expand
Neuroanatomical Pathways Related to Vasopressin
Vasopressin and oxytocin are hormones of the neurohypophysis best known for their peripheral endocrine effects: regulation of antidiuresis and blood pressure, contraction of smooth muscles of the uterus during labour and of the mammary gland during milk ejection respectively. Expand
Oxytocin as an Ovarian Hormone
The synthesis, secretion and actions of hypothalamic oxytocin are covered extensively in the rest of this volume, but a number of recent reports have confirmed an earlier observation that the corpus luteum also contains a hormone with an oxytocic action. Expand
Neurohypophysial peptides in the gonads: are they real and do they have a function?
The vasopressin-like peptides that also occur in the gonads are focused on and the reader is directed to work on such peptides by reference at the appropriate places, and further consideration can be found in the reviews by Clements and Funder and Wathes. Expand
Oxytocin and Vasopressin Are Present in Human and Rat Pancreas
The finding of oxytocin and vasopressin in the pancreas raises the possibility, although yet unproven, of local synthesis and perhaps a paracrine function for the neurohypophysial peptides upon pancreatic hormone release or for a local function upon the liver. Expand
Isolation and sequence analysis of oxytocin from the sheep corpus luteum
This study represents the first identification by sequence analysis of oxytocin outside the central nervous system and established by Edman degradation and comparative reverse-phase HPLC its identity with hypothalamic Oxytocin. Expand
Gonadal sources of the posterior pituitary hormones.
Both oxytocin- and vasopressin-related neurophysins indicate that synthesis of these neuropeptides may occur in the testis, as well as the ovary, and the most exciting possibility is that these peptides may provide a local feedback control system on steroid biosynthesis within the gonad. Expand
Direct regulation of Leydig cell functions by neuropeptides
Since pituitary gonadotropins are essential for normal gonadal functions, treatment with high doses of GnRH or its agonists had been predicted to be a potential means for enhancing fertility, but early studies using GnRH as an ovulation-inducing agent in anovulatory women have been only partially successful. Expand


Variations of neurohypophysial function in normally cycling women.
Using a neurophysin radioimmunoassay, data provide additional evidence for a relationship between estrogens and neurohyprophysial function, as previously shown following exogenous administration of estriol and ethinyl estradiol in man. Expand
Variations in plasma concentrations of vasopressin during the menstrual cycle.
Vasopressin release in women may depend on the hormonal changes during the menstrual cycle, as determined by radioimmunoassay. Expand
Is oxytocin an ovarian hormone?
The discovery of large amounts of oxytocin within the ovine corpus luteum reported here may provide an explanation of why there may exist different controls of reflex release and basal secretion of Oxytocin. Expand
Ovarian secretion of oxytocin is stimulated by prostaglandin
It is shown that in sheep, the concentration of oxytocin in ovarian venous blood exceeds that in arterial blood, and it is found that ovarian secretion of Oxytocin is stimulated by a prostaglandin F2α analogue. Expand
Delayed luteal regression in ewes immunized against oxytocin.
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Elevation of oxytocin and the oxytocin-associated neurophysin in the plasma of normal women during midcycle.
A positive correlation was observed between the midcycle elevation of estrogen (E) and the level of oxytocin- and estrogen-stimulated neurophysin (ESN) in the plasma of five of six women, the only described cyclic secretion of Oxytocin in humans. Expand
Oxytocin Release by Infused Prostaglandin
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Alteration of the Bovine Estrous Cycle with Oxytocin
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