NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.

@article{Lacomme2012NEUROG2DC,
  title={NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.},
  author={Marine Lacomme and Laurence Liaubet and Fabienne Pituello and Sophie Sophie Bel-Vialar},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 13},
  pages={
          2596-607
        }
}
Proneural NEUROG2 (neurogenin 2 [Ngn2]) is essential for neuronal commitment, cell cycle withdrawal, and neuronal differentiation. Although NEUROG2's influence on neuronal commitment and differentiation is beginning to be clarified, its role in cell cycle withdrawal remains unknown. We therefore set out to investigate the molecular mechanisms by which NEUROG2 induces cell cycle arrest during spinal neurogenesis. We developed a large-scale chicken embryo strategy, designed to find gene networks… CONTINUE READING

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