NEUROACTIVE STEROIDS

@article{Paul1993NEUROACTIVES,
  title={NEUROACTIVE STEROIDS},
  author={Steven M Paul},
  journal={Pediatric Research},
  year={1993},
  volume={33},
  pages={S9-S9}
}
  • S. Paul
  • Published 1 March 1992
  • Biology, Medicine, Chemistry
  • Pediatric Research
It is now well accepted that certain steroids rapidly alter the excitability of neurons via non-genomic mechanisms, resulting in behavioral effects within minutes following parenteral administration. Almost 50 years ago Selye first identified the sedative/anesthetic properties of pregnane and androstane steroids including the 3α-hydroxy A-ring reduced metabolites of progesterone and deoxycorticosterone, allopregnanolone and allotetrahydroDOC respectively. We have shown that these 3α-hydroxy A… 
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Two metabolites of the steroid hormones progesterone and deoxycorticosterone are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons, which may explain the ability of certain steroid hormones to rapidly alter neuronal excitability.
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TLDR
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