NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.

@article{Khandpur2013NETsAA,
  title={NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.},
  author={Ritika Khandpur and Carmelo Carmona-Rivera and Anuradha Vivekanandan-Giri and Alison M. Gizinski and Srilakshmi Yalavarthi and Jason S. Knight and Sean C Friday and Sam Li and Rajiv M Patel and Venkataraman Subramanian and Paul F Thompson and Pojen P. Chen and David A Fox and Subramaniam Pennathur and Mariana J Kaplan},
  journal={Science translational medicine},
  year={2013},
  volume={5 178},
  pages={178ra40}
}
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET) formation, a phenomenon that exposes autoantigens in the context of immunostimulatory molecules. We investigated whether aberrant NETosis occurs in RA, determined its triggers… CONTINUE READING