NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo

  title={NET occupancy by clomipramine and its active metabolite, desmethylclomipramine, in non-human primates in vivo},
  author={A. Takano and S. Nag and B. Guly{\'a}s and C. Halldin and L. Farde},
  • A. Takano, S. Nag, +2 authors L. Farde
  • Published 2011
  • Chemistry, Medicine
  • Psychopharmacology
  • RationaleNorepinephrine transporter (NET) is one of the key targets for antidepressants such as combined serotonin and norepinephrine reuptake inhibitors as well as some of the tricyclic antidepressants. Clomipramine, a tricyclic antidepressant, has been reported to have an active metabolite, desmethylclomipramine, which has high affinity for NET in vitro. However, the NET occupancy of clomipramine and desmethylclomipramine has not fully been evaluated in vivo.ObjectivesIn this positron… CONTINUE READING
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