NERD, a plant-specific GW protein, defines an additional RNAi-dependent chromatin-based pathway in Arabidopsis.

@article{Pontier2012NERDAP,
  title={NERD, a plant-specific GW protein, defines an additional RNAi-dependent chromatin-based pathway in Arabidopsis.},
  author={Dominique Pontier and Claire Picart and François Roudier and Damien Garcia and Sylvie Lahmy and Jacinthe Azevedo and Emilie Alart and Mich{\`e}le Laudi{\'e} and Wojciech M. Karlowski and Richard Cooke and Vincent Colot and Olivier Voinnet and Thierry Lagrange},
  journal={Molecular cell},
  year={2012},
  volume={48 1},
  pages={121-32}
}
In Arabidopsis, transcriptional gene silencing (TGS) can be triggered by 24 nt small-interfering RNAs (siRNAs) through the RNA-directed DNA methylation (RdDM) pathway. By functional analysis of NERD, a GW repeat- and PHD finger-containing protein, we demonstrate that Arabidopsis harbors a second siRNA-dependent DNA methylation pathway targeting a subset of nonconserved genomic loci. The activity of the NERD-dependent pathway differs from RdDM by the fact that it relies both on silencing-related… CONTINUE READING