NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

  title={NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury},
  author={Yan Lin and Chun-Hui Li and Jian Li and Ruolan Deng and Juan Huang and Qinglian Zhang and Jiayao Lyu and Na Hao and Zhirong Zhong},
  journal={Journal of Nanobiotechnology},
BackgroundFrequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal… 

Minocycline-Loaded Poly(α-Lipoic Acid)–Methylprednisolone Prodrug Nanoparticles for the Combined Anti-Inflammatory Treatment of Spinal Cord Injury

The design, synthesis, release kinetics, biosafety, and preclinical efficacy of minocycline (MC)-loaded poly(α-lipoic acid)–methylprednisolone (PαLA-MP) prodrug nanoparticles (NPs) for the combined anti-inflammatory treatment of TSCI are described, suggesting their potential for clinical application.

Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury

The results of this study demonstrate that the local treatment of acute SCI with MPS in the form of mixed micelles with TBC can provide improved therapeutic outcome by promoting drug accumulation and functional restoration of the spinal cord.

Triptolide improves spinal cord injury by promoting autophagy and inhibiting apoptosis

TP mediates its protective effect in SCI by promoting the autophagic pathway while inhibiting the MAPK/ERK1/2 signaling pathway, and shows improved motor functions, and reduced neuronal cell death.

Serum albumin: clinical significance of drug binding and development as drug delivery vehicle.

Recent progress in therapeutic drug delivery systems for treatment of traumatic CNS injuries.

In this review, the pathophysiology and biomarkers of traumatic central nervous system injuries (traumatic brain injury and spinal cord injur) are introduced and various drug delivery systems, novel combinatorial therapies and advanced therapies for the treatment of traumatic brain Injury and spinal Cord injur are emphasized.

Double-Controlled Release of Poorly Water-Soluble Paliperidone Palmitate from Self-Assembled Albumin-Oleic Acid Nanoparticles in PLGA in situ Forming Implant

A combined formulation of AOC and PLGA was found to effectively control the initial burst release of the drug, and the larger the volume of the solvent, the smaller the size of the AONs.



Localized delivery of methylprednisolone sodium succinate with polymeric nanoparticles in experimental injured spinal cord model

It is believed that developed nanoparticle-gel combined drug delivery system may be used as a tool for the safe and effective localized delivery of several other therapeutic molecules on injured spinal cord cases.

Synthesis of methylprednisolone loaded ibuprofen modified dextran based nanoparticles and their application for drug delivery in acute spinal cord injury

It is demonstrated that methylprednisolone loaded ibuprofen modified dextran based nanoparticles (MP-loaded NPs) could promote the recovery of neurological deficits, enhance growth of neurons, decrease degeneration of injuried neurons and reduce the tissue tumor necrosis factor alpha levels significantly in the SCI rats.

Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury.

  • A. GorioL. Madaschi M. Brines
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
It is suggested that glucocorticoids should not be coadministered in clinical trials evaluating the use of EPO for treatment of SCI and coadministration of MPSS antagonized the protective effects of EPo, even though the EPO receptor was up-regulated normally after injury.

TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke

The data suggest that TAT-NEP1-40 may be a novel therapeutic candidate for axonal regeneration and functional recovery from CNS injuries such as cerebral hypoxia-ischemia, cerebral hemorrhage, brain trauma, and also for spinal cord injury.

Methylprednisolone Protects Oligodendrocytes But Not Neurons after Spinal Cord Injury

It is suggested that MP selectively inhibits oligodendrocyte but not neuronal cell death via a receptor-mediated action and may be a mechanism for its limited protective effect after SCI.

Biomimetic Human Serum Albumin Nanoparticle for Efficiently Targeting Therapy to Metastatic Breast Cancers.

The proof of concept for Wpep-HSA NP as a promising conqueror to the ineffectiveness of TNBC therapy was highlighted, exhibiting the improved antiproliferation and antitube formation effects of PTX in vitro.

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

Loperamide-loaded HSA NP with covalently bound insulin or the 29B4 antibodies induced significant antinociceptive effects in the tail-flick test in ICR (CD-1) mice after intravenous injection, demonstrating that insulin or these antibodies covalent coupled to HSANP are able to transport loperamide across the blood–brain barrier (BBB) which it normally is unable to cross.

Ligand-Modified Human Serum Albumin Nanoparticles for Enhanced Gene Delivery.

Ligand-functionalized HSA nanoparticles represent promising tools for efficient and safe gene therapy and show the highest transfection potential.