NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

@article{Lin2019NEP140modifiedHS,
  title={NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury},
  author={Yan Lin and Chun-Hui Li and Jian Li and Ruolan Deng and Juan Huang and Qinglian Zhang and Jiayao Lyu and Na Hao and Zhirong Zhong},
  journal={Journal of Nanobiotechnology},
  year={2019},
  volume={17}
}
BackgroundFrequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can encapsulate therapeutic drugs and release cargo in a controlled pattern, show high biocompatibility and low toxicity. The Nogo protein, expressed on the surface of oligodendrocytes, can inhibit axonal… 

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